Fifteen-year-old American qualifier Cori Gauff caused a stunning upset by defeating five-time Wimbledon champion Venus Williams in the first round.
World number 313 Gauff beat Williams, 24 years her senior at 39, 6-4 6-4.
Fellow American Williams had won four Grand Slam titles, including two at Wimbledon, before Gauff was born.
But Gauff, whose school teachers did not know she played tennis until this week, was left in tears as she clinched victory over her “idol”.
Second seed Naomi Osaka was also dumped out in the first round, losing 7-6 (7-4) 6-2 to Yulia Putintseva of Kazakhstan.
Japan’s Osaka, the US and Australian Open champion, has suffered a dip in form in recent months and struggled throughout her match on Centre Court.
She was 3-1 up before she was broken back and edged out in the tie-break.
Osaka was then broken in the fifth and seventh games, before her 38th unforced error gave the world number 39 victory.
“That’s amazing,” said 24-year-old Putintseva, who also defeated Osaka at the grass-court event in Birmingham in June.
“I had never been on that court, I did a good job out there. I’m very happy now.
“Every match is a battle, but you never know what’s going to happen. I was hoping I would do my best.”