Netherlands team were at their best against Turkey as Barcelona star, Depay scored hat-trick to make his international goal tally to 33 goals.
The Dutch led 3-0 by half-time and Turks chance of coming back ended after Leicester defender Caglar Soyuncu was sent off after receiving second yellow shortly before the break.
Louis van Gaal’s side moved into top spot in Group G by virtue of goal difference above Norway who beat minnows Gibraltar 5-1, with Erling Braut Haaland bagging a hat-trick.
Serbia’s bid to qualify for a second successive World Cup finals suffered a setback as Nikola Milenkovic’s die minutes own goal and excellent display from goalkeeper Gavin Bazunu gave the Republic of Ireland a battling 1-1 draw in Dublin.
The Portuguese did not miss absence of Cristiano Ronaldo who was suspended against Ireland as Bernardo Silva scored a sparkling opener on 26 minutes before Andre Silva added a second five minutes later in Baku.
Liverpool forward, Diogo Jota sealed the winning as he scored third goal in second-half to continue his bright early season form.
Defending champions, France beat Finland 2-0 in a World Cup qualifier on Tuesday with Antoine Griezmann scoring two goals to snap a five-game winless streak while Scotland kept their hopes alive with a 1-0 win in Austria.
Portugal and the Netherlands stayed on track to book their place in next world cup, with Memphis Depay bagging a hat-trick for the Dutch in a 6-1 demolition of Turkey.
France were supported by 57,000 passionate spectators in Lyon where Griezmann who ended struggling spell at Barcelona with a loan move back to Atletico Madrid in the transfer window.